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A large-scale lifespan analysis using eight hundred mice demonstrated that DR only in the period of 3-24 months can extend lifespan, although the mortality rate is acutely increased upon swapping diet-restricted animals to normal chow 7

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One such option would be utilizing antioxidant therapies to neutralize reaction oxygen species (ROS) in the retina that underlie RP progression

Two main strategies for targeting Cu homeostasis have been proposed, including the use of Cu chelators to decrease Cu bioavailability, and the use of Cu ionophores to deliver Cu into cells in order to increase intracellular Cu levels

Furthermore, intravenous glutathione (12 injections of 1,200 mg) showed no benefit for skin lightening compared to placebo in a Pakistani study (Zubair et al., J Pakistan Assoc Dermatol, 2016) [64]