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Moreover, excessive APAP increases hepatic CXCL16 levels, CXCL16 deficiency significantly reduces the production of pro-inflammatory cytokines TNF- and IL-6, and inhibits neutrophils migration to the site of injury, other chemokines CXCL1 and CXCL2 expression are also diminished, suggesting that CXCL16 may be involved in neutrophil infiltration in APAP hepatotoxicity [38]

Singlet oxygen ( 1 O) 1 O is a high energy state of oxygen characterized by its potent oxidative capacity and propensity for reacting with various biomolecules [86]

Markers of NF-B activation, elevated in aging hearts, were reduced

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