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A physician should be consulted to evaluate other options if pain is not relieved by conservative methods

Neurologic effects can include ataxia, nystagmus, confusion, and rarely encephalopathyparticularly if ammonia levels rise or in interactions (e.g., with topiramate)

NPSI, Neuropathic Pain Symptom Inventory

In peripheral white adipocytes, PTH and PTHrP stimulate lipolysis via PKA-mediated phosphorylation of HSL and PLIN1 and beiging via the upregulation of thermogenic genes including Ucp1, Dio2 , and Pgc1a (74, 210, 258, 275)

While there is no incidence data specific to cholestatic DILI, a figure of 1.47 per 300,000 can be extrapolated from data reported by Bjrnsson et al