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Knockdown of NNMT significantly increased microRNA (miR)-449a levels and decreased the levels of active Akt in vivo in that miR-449a reduced PTEN methylation

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The experiment investigated the potential cytotoxicity of these factors using in vitro keratinocyte and fibroblast cell assays

Interestingly, NNMT expression was elevated in atorvastatin- and pravastatin-treated endothelial cells, which elevated nitric oxide and reactive oxygen species (ROS) (35)
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