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In addition, MTHFD2 deficiency also promotes Treg cell differentiation (75)
Given the multi-factorial nature of secondary injury, many different therapeutic approaches have been investigated in an attempt to mitigate the post-acute neuronal damage caused by TBI including antioxidants, neurorestorative therapies, neuroprotective pharmacological agents, and drugs that modulate neuroinflammation (Hall et al., 2010

Folic acid and vitamin B12 supplementation in subjects with type 2 diabetes mellitus: A multi-arm randomized controlled clinical trial
Gelatin acts like a soft cushion between bones that helps them move smoothly without friction

Crit Rev Ther Drug Carrier Syst 30:435467
