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The role of the H 2-catalytic core interaction was assessed in human PLC 3, where point mutations in H 2 or its binding site on the catalytic core decreased the thermal stability of the enzyme and increased basal activity up to 50-fold over wild-type PLC 3 (Lyon et al., 2011)

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In another experiment, rats were given a combination of LC and lipoic acid to see how it affected age-dependent apoptosis in skeletal muscle fibers ( Table 1 ) (Tamilselvan et al., 2007)