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In cellular models of ALS the RNA processing gets severely impaired upon oxidative stress, in turn causing the mis-localization of TDP-43 and FUS ( Another major factor contributing to the pathophysiological mechanisms in ALS is excitotoxicity, triggered by excessive postsynaptic glutamate receptor stimulation
On occasion the Botulinum Toxin may go to area that is unintended, in rare cases this can cause facial droop or weakness of the muscle
doi: 10.18632/oncotarget.18798
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