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Glutathione depletion and formaldehyde dehydrogenase 18

Recent studies further connect sustained Ca 2+ entry (via NMDAR or P2X7) to loss of mitochondrial membrane potential, increased mitochondrial ROS, and suppression of mitophagic clearance, collectively potentiating NLRP3 activation in microglia under HIV-related conditions [100]

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Beyond the mirror: metabolic, immune &
