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Dimerization of the scaffolding protein ZO-1 through the second PDZ domain

The major causes are imbalanced fatty acid composition in the diet, high lipid content, and the ingestion of oxidized fats

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Given the high lipophilicity of the BBBs endothelial cells, chemical modification primarily enhances passive diffusion by improving the lipid solubility of carriers or drugs (Zhou et al., 2018
