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TRPC channels have been shown to be activated by PLC [68], possibly through direct actions of DAG [69, 70] generated through PLC activity [26]

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Milk thistle is also indicated in a number of conditions that are caused by oxidative stress and where there has been exposure to pollutants, chemicals and other toxins such as liver or cardiovascular diseases (8)

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(87,88) Notably, R EL is very relevant during transient operation, whereas it can be neglected under steady-state operation and in the absence of parasitic leakage currents