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95% CI 3.65, 1.95), GLP-1 RAs (WMD: 1.9

Source: West, S et al Weight regain after cessation of medication for weight management: systematic review and meta-analysis, BMJ January, 2026 Newer incretin mimetics are the GLP-1 medications semaglutide and tirzepatide

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In a head-to-head competition of diet/exercise versus semaglutide, after 16 months, overweight patients following diet/exercise alone lost 2% of their weight, but semaglutide users lost 20%