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Clinical trials have shown improvements in hepatic steatosis, liver inflammation, and liver enzyme levels through the medication's weight loss effects

We examine the profound dysregulation of the gelatinases and collagenases MMP-2, 8, and 9, exploring how their hyper-activation transitions from localized tissue destructionsuch as hair follicle rupture and sinus tract formationto systemic inflammatory and metabolic complications

Since leptin is released by excitation of vagal nerves by sham-feeding, that operates entirely via brain-gut axis (49), it may be assumed that gastroprotective and hyperemic effects of leptin are centrally mediated, at least in part, by the activation of sensory vagal fibers (50)

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