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Statistical analysis We used cumulative incidences and cause specific hazard regression to estimate hazard ratios (HR) and 95% confidence intervals (CI) for risk of suicide and suicide attempts in GLP-1 RA users vs SGLT-2 inhibitor users or DPP-4 inhibitor users, taking death as a competing risk to suicide into account

Among GLP-1RAs, liraglutide and semaglutide have particularly shown high efficacy in promoting satiety, reducing appetite, and regulating blood glucose levels

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HR, 1.76

In supportive logistic regression analysis, semaglutide was associated with substantially higher odds of achieving 10% weight loss at 6 months (OR 14.84