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Results from Eli Lilly's Phase 2 trial (Jastreboff et al., New England Journal of Medicine, 2023) reported mean body weight reductions of approximately 1724% over 48 weeks depending on dose, which has generated considerable scientific interest

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DHEAS protected cultured rat cerebellar granule cells against the toxic effects of glutamate, NMDA, 1-methyl-4-phenylpyridinum (MPP+) and colchicine [138]

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