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doi:10.1056/NEJMra2000348 Hoeper MM, Humbert M, Souza R, et al

Koletsky rats Rats that are homozygous for a nonsense mutation in the leptin receptor gene, causing lack of leptin receptor function and hence altered metabolic homeostasis

By acting on the pituitary gland, these peptides encourage the release of human growth hormone (HGH), which plays a crucial role in various bodily functions

Shimomura I, Bashmakov Y, Horton JD