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For obesity trials, however, it can miss a crucial question: Where are the patients actually located

Molecular-level observations also add to the evidence that GLP-1 is active in the brain

Finally, be cautious with programs that promise guaranteed results, prescribe without a meaningful medical review, or make it difficult to reach a licensed clinician

Its often not the best time for food restriction or unnecessary weight loss in healthy-weight women

Exercise selection (joint-friendly for women 40+): Cable squats or leg press (instead of heavy back squats) Romanian deadlifts or hip thrusts Dumbbell chest press (incline or flat) Cable or dumbbell rows Lat pulldowns or assisted pull-ups Overhead press Planks and dead bugs for core Volume: 10-15 hard sets per muscle group per week