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They are also overexpressed in insulinomas and medullary thyroid carcinomas [38]

Specifically, liraglutide blocked increased IL-6 levels in colonic mucosa via a nitric oxide-mediated response

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Nevertheless, more studies in various models of cardiometabolic disease are needed to confirm the cardioprotective mechanisms, especially considering that there is limited evidence available to elucidate the mechanistic details regarding the cardiovascular biology or long-term safety of selective GIPR agonism in humans (Hammoud & Drucker 2023)