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In addition, the NTS houses numerous neuropeptides that are capable of modulating HPA axis stress responses, including glucagon-like peptide-1 (GLP-1), somatostatin, substance P, neuropeptide Y and enkephalin [15, 18, 35]

These findings emphasize the importance of GIPR activity and its anti-sclerotic role [32,33,34]

Since then, Noom has generated significant real-world data showing that even very small doses of GLP-1 medications, combined with Nooms proven digital behavior program, can deliver meaningful metabolic benefits

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25 Ala substitutions in positions 10 and 11 of GIP had little negative effect on insulinotropic activity while position 12 and 14 mutations had a greater negative effect