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While effective and free of hepatotoxicity, high rates of nausea (70%) and vomiting (67-69%) pose challenges for global studies

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reduced form)-dependent buffering systems, several constraint-sensitive metabolic processesincluding NAD partitioning, amino aciddependent antioxidantanabolic coupling, micronutrient-dependent enzymatic activity, and bile acidmediated absorptionmay become functionally limiting

The risks have come into sharp focus during the present pandemic