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Additional perioperative risks associated with Wegovy include: Hypoglycaemia : Uncommon with GLP-1 agonists alone, but risk increases when combined with insulin or sulfonylureas, particularly in patients with diabetes who are fasting perioperatively [1] [2] Nausea and vomiting : Common side effects that may complicate post-operative recovery and fluid management Dehydration : Patients experiencing nausea may have reduced oral intake before surgery Cardiovascular effects : Semaglutide is associated with a small mean increase in heart rate (approximately 2-3 beats per minute according to the SmPC), which may interact with anaesthetic agents [1] [2] Several case reports have documented aspiration events in patients on GLP-1 agonists despite standard fasting protocols

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