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Brain GLP-1Rs, rather than peripheral GLP-1Rs, appear crucial for the weight-reducing effects of GLP-1RAs
In the LEADER trial, over 9,340 patients with type 2 diabetes and high cardiovascular disease risk underwent randomization to liraglutide or placebo and were followed for a median of 3.8 years resulting in a 13% risk reduction in a combined endpoint of death from cardiovascular cause, nonfatal myocardial infarction, or nonfatal stroke [46]
Journal of the American Pharmacists Association: JAPhA, 63 (5), 16431645
However, as with any peptide protocol, medical supervision and regular monitoring optimize both safety and results
