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However, temporary changes in appetite and side effects are common during the transition

It activates GLP-1 receptors (slowing gastric emptying, suppressing glucagon, increasing satiety) and GIP receptors (influencing insulin sensitivity and fat metabolism)
Source: Zepbound Prescribing Information, Eli Lilly and Company, 2024

When those receptors change signaling in the gut and brain, you get weight loss benefits, and the same pathways also cause many of the side effects people feel

Postpartum weight loss through nutrition and exercise alone typically takes 6 to 12 months to reach pre-pregnancy weight