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Sodium Glucose Cotransporter-2 Inhibition in Heart Failure: Potential Mechanisms, Clinical Applications, and Summary of Clinical Trials

Non-exercise activity thermogenesis contributes significantly to daily calorie expenditure

These actions help lower blood sugar levels and improve glycemic control in people with type-2 diabetes
Among the main obstacles are the complicated interactions between genetic and environmental variables, poor adherence to lifestyle modifications, and restricted access to therapies, especially in low- and middle-income countries

doi:10.2337/db08-0958 19