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The results of different clinical studies are so far inconclusive and they vary much, depending on experimental design, sample size, health conditions and the chosen rating scale used to asses depressive symptoms in participants

Going forward, several key considerations should be addressed to further expand our understanding and optimize the use of GLP-1 RAs and SGLT2is in PCOS: Longer-term studies: The current trials have relatively short durations, necessitating the need for longer-term studies to assess the sustained efficacy and safety of these interventions in PCOS

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Patient initiation and maintenance of GLP-1 RAs for treatment of obesity: A narrative review and practical considerations for primary care providers