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This titration approachcalled step dosingallows your body to adapt and helps minimize gastrointestinal side effects

This work was supported by National Institutes of Health Grants DK123252 (P.M.T.), Cox Research Institute and internal funds from the University of Pennsylvania (P.M.T.) Data availability Data will be made available on request

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If a dose was missed and the next scheduled dose was less than 2 days (48 hours) away, the patient was not to administer a dose until the next scheduled dose