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Database Characteristics We utilized the TriNetX database (US Collaborative Network), which includes de-identified electronic medical records from 67 healthcare organizations (HCO)

SURMOUNT1) for obesity, a subset of participants also had body composition analyzed by DXA before and at the end of the 72week treatment period (see supplementary appendix in Jastreboff et al

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The angiotensin II evaluation was also planned in our protocol, but measurements were not finally performed due to technical difficulties in our research laboratory

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