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A systematic review of tirzepatide and skeletal muscle mass concluded that the medication induces significant fat mass loss while preserving a relatively stable proportion of lean mass and improving markers of muscle composition

According to the Global Burden of Disease Study, both type 1 and type 2 diabetes mellitus substantially contribute to chronic kidney disease (CKD)-related disability-adjusted life-years (DALYs)

Expert Rev Clin Pharmacol (2017) 10(4):4018

Am J Physiol Endocrinol Metab 308: E583E591
