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Description
Stress responses are mediated by both autonomic (fight or flight) responses and glucocorticoid hormone release by the hypothalamo-pituitary-adrenocortical (HPA) axis

Previous studies suggested that both PKC activation and increased intracellular Ca 2+ levels are required for TRPM5 activation [24]

It also plays a role in certain behaviors

The ones who keep it off long-term

A lower dose may let you try again without the bathroom drama
