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SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin
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We observed that cAMP responses across cells varied on a continuum, said co-corresponding author Michael Krashes, Ph.D., a senior investigator at NIDDK
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They can also slow gastric emptying and promote satiety
