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This makes them especially valuable for patients with complex health profiles

This occurs because caloric restriction and rapid weight loss can trigger the body to break down muscle tissue for energy

doi: 10.1016/b978-0-12-394440-5.00005-x

However, the benefits must be weighed against the increased risk of adverse effects

There was a significant reduction in tumor volumes observed only in the metformin group and not the exendin4 group in athymic mouse tumor models