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Yes, switching from Saxenda to semaglutide is straightforward and commonly done

In comparison to placebo, liraglutide reduced activation of the parietal cortex and of insula and putamen (areas involved in the reward system) in response to pictures of highly palatable foods [4]

For example, ghrelin can promote food motivated behaviors by driving impulsivity as both icv and VTA infusion of ghrelin increases the rates of impulsive responding in rats assessed in tasks of differential reinforcement of low rates of responding (DRL), go/no-go, and delay discounting [93]

IR -subunit heterozygous mice135 and complete disruption of IRS2 in mice136 impaired the LTP of synaptic transmission in the hippocampus
