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While you cannot eliminate the risk entirely, certain practices help reduce severity: start with the lowest dose (0.25 mg weekly), escalate slowly, maintain excellent hydration, eat smaller meals, and avoid high-fat and high-fiber foods during the first 4 weeks

[DOI] [PubMed] [Google Scholar] 234.Nikolaidis LA, Elahi D, Shen Y, Shennon RP

Advantage : Semaglutide Side Effect Profile# MET-097i : Limited safety data from Phase 1/2 and Phase 2b trials

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Dosage and Adjustments Typically starts at 0.25 mg once a week, increasing gradually to minimize side effects