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"You rebound the fat mass much faster than muscle, so you actually start impinging pretty heavily on lean muscle if you go through multiple rounds of these cycles," Pye said at the Biotech Showcase panel

Generally, GLP-1s are well tolerated and dont appear to cause severe adverse events in most people, particularly semaglutide

doi: 10.3389/fddsv.2026.1792418 Received 20 January 2026 Revised 11 March 2026 Accepted 16 March 2026 Published 10 April 2026 Volume 6 - 2026 Edited by Liang Xu, University of Kansas, United States Reviewed by Christel Menet, Confo Therapeutics, Belgium Anukriti Saran, Banasthali University, India Updates Copyright 2026 Niazi

You must undergo a medical assessment, which ensures the medication is safe and appropriate for you

As a result, obesity poses a ~30% increased risk for all-cause death for every five kg/m 2 increase in body mass index (BMI) and remains an unmet area of clinical and public health need 3