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Description
In 'Bench to Bedside,' Keval Chandarana and Rachel Batterham examine how two different methods of bariatric surgery highlight the relevance of gut-derived hormones not only in inducing sustained weight loss but also in improving glucose homeostasis

(22:15) The musculoskeletal impacts of GLP-1s

With GLP1 therapeutics entering their second wave of innovation, this is a pivotal moment for teams pushing boundaries in metabolic and neuroendocrine drug development

Similarly, the specific blocking of Gq signalling with YM254890 or transient receptor potential melastatin 5 (TRPM5) with triphenylphosphine oxide (TPPO) suppressed the triagonist-induced enhancement of GSIS

Background/objectives: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used in treating type 2 diabetes and obesity, offering established metabolic and cardiovascular benefits
