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The most commonly reported symptoms include: Cycle changes: Heavier periods, longer periods, shorter cycles, irregular cycles Physical changes: Weight gain, sore breasts, changes in libido, vaginal dryness Sleep changes: More frequent waking, difficulty getting to sleep, insomnia Mood changes: More frequent mood changes, irritability, rage and increased PMS Vasomotor changes: Onset of night sweats, hot flushes New allergy symptoms: Hayfever-type symptoms or the onset of new allergies What's Happening to Our Hormones over the Four Stages of Perimenopause

Since semaglutide is often prescribed for diabetes management or weight loss, excessive drinking may counteract its intended effects

Synthroid is a thyroid hormone replacement for those with low thyroid function

Many common side effects ease as the body adjusts, but the course varies

Ethics declarations Funding Both trials were sponsored by Novo Nordisk A/S, Sborg, Denmark