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doi:10.1007/s001250051484

Prior to SSRIs, TCAs, and MAOIs dominated depression pharmacotherapy but carried significant anticholinergic, cardiovascular, and dietary interaction risks that necessitated the development of more selective and tolerable agents [3]
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The net effect on overall comfort can vary, for example, if diarrhoea was the more troublesome symptom for you, semaglutide might feel like a net win despite some constipation, or vice versa

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