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Drugs used off label to treat raised ICP also have cognitive side effects, underscoring the unmet need for effective therapeutics which reduce ICP without worsening cognition

Studies show these drugs can lead to significant weight loss

Although Glp1r expression is mostly localized to endothelial cells in the mouse aorta (29), other vascular cell types may express Glp1r under atherogenic conditions, making it difficult to pinpoint which cell type mediates the antiinflammatory effects of GLP-1 medicines

These medications belong to a class of glucagon-like peptide-1 (GLP-1) receptor agonists and are marketed under brand names such as Ozempic, Wegovy, Victoza, and Saxenda

This chart perfectly illustrates their major classifications: Non-Selective COX Inhibitors: The classics like Aspirin and Ibuprofen