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Exploratory analyses generally showed greater reductions in body weight and HbA1c over 24 months in the incretin-based therapy groups than in the conventional anti-obesity medication groups, although some comparisons varied by diabetes status and outcome measure

Breathing difficulty , especially when lying flat or during mild exertion, combined with weight gain is a potential sign of fluid accumulation around the lungs (pleural effusion) or worsening heart function

J Neuroophthalmol, 21:121-123

Risks Despite the strong clinical data, the investment case built around Retatrutide carries risks worth considering: Regulatory risk