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GLP-1 receptor agonists do not directly increase serotonin, so they carry minimal risk of triggering serotonin syndrome when combined with Zoloft at standard therapeutic doses

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In the vast majority of trials, symptoms are evaluated by participant self-report that, while simple, has major limitations (26)

These side effects are usually temporary and can be managed with over-the-counter medications, staying hydrated, and eating smaller, more frequent meals