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Subsequent studies demonstrated that centrally administered GLP-1 also induces an aversive response and activates sympathetic nervous system pathways, potentially indirectly controlling brown adipose tissue thermogenesis (8)

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Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review

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Potential mechanisms by which SGLT2i may reduce the risk of PsA include the following: (1) SGLT2i promote fat utilization and induce the browning of adipose tissue, thereby attenuating obesity-related inflammation by shifting macrophage polarization toward the anti-inflammatory M2 phenotype