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Research suggests yes through direct effects on inflammatory pathways, gut health, insulin resistance, and oxidative stress that don't depend on losing weight, which is part of why low-dose "microdosing" can help

Obesity should be seen as a lifelong condition

Specifically, it increases POMC and CART expression in the hypothalamus, the peptides that tell your brain you are full

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GLP1 receptor agonist use was shown to be associated with a reduction in the risk for progression to cirrhosis in patients with MASLD and diabetes, and who started the medication early in the course of their disease, 13 leading the FDA to approve semaglutide for this condition in August 2025