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Similarly, blockade of GLP-1R with an antagonistic monoclonal antibody demonstrated an important contribution of enhanced GLP-1 secretion to the improved insulin secretion and glucose handling after vertical sleeve gastrectomy (VSG) in preoperatively lean mice [144]
Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice
In that study, a single administration of rAd-GLP-1 via the tail vein into streptozotocin (STZ)-induced diabetic non-obese diabetic/severe combined immunodeficient (NOD/SCID) mice resulted in remission of diabetes within 10 days

The damage was often severe and required surgical intervention

Clinicians should counsel patients that while preclinical data appear promising, cognitive enhancement remains an investigational application requiring further study
