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The ability of GLP-1RAs to access the CNS has become a central consideration in understanding their potential role in modulating neuropsychiatric and reward-related processes, including addiction

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In order to rule out direct glucose effects on the macro- and microvascular event rate, glucose parameters are kept as closely overlapping as possible (5456)

The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for Diabetes Management in CKD 13 recommended first-line use of metformin for kidney transplant recipients with T2D and estimated glomerular filtration rate (eGFR) 30 mL/min/1.73m 2 , noting that future studies were needed to confirm safety and clinical benefit of GLP-1RAs

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