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Another plausible mechanistic explanation for a diminished incretin effect is the TCF7L2 -dependent repression of GLP-1R and GIPR expression on the -cells [569]

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Conclusion In summary, high-protein foods, prebiotics, healthy fats, and probiotics can increase our natural GLP-1 secretion, as can supplements such as berberine, omega-3s, and certain probiotic strains

There is no absolute contraindication to consuming alcohol while taking tirzepatide (Mounjaro, Zepbound), and the FDA-approved prescribing information does not list alcohol as a formal drug interaction

Nevertheless, individual patient factors, including the presence of other autoimmune conditions, cardiovascular risk factors, and previous tolerance of weight loss interventions, should inform the prescribing decision