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Gastrointestinal adverse events were commonly reported but mild in severity, while three patients experienced asymptomatic cardiac disorders [90]

However, one of the earliest studies, performed more than 15 years ago, administered the GLP-1 receptor agonist exendin-4 to db/db mice, a model of T2D (56)

Like Ozempic , metformin isnt FDA-approved for weight loss, but doctors sometimes prescribe it off-label, particularly for: People with a BMI of 30 or higher or People with a BMI of 27 or higher and at least one weight-related condition

For some people it makes sense

This is more common in people taking additional diabetes medications