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Adjusting Calorie Intake as You Lose Weight As you lose weight over weeks and months, your maintenance calorie needs decreasea shift many patients overlook, leading to weight loss plateaus

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( 3.3 Development of unimolecular agents targeting both GIPR and GLP-1R The anti-obesity effects of GIPR antagonism antibody, both alone and in combination with GLP-1RAs, have been demonstrated in preclinical models of mice and monkeys (68, 73)

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