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Description
Preliminary studies indicate that combining GLP-1RAs with opioids may lead to a decrease in the dose of opioids necessary, thereby decreasing the risk of opioid addiction and side effects [109]

Understandably, demand skyrocketed quickly outstripping manufacturing capacity and leaving the Danish company racing to expand supply
Discussion In individuals with type 2 diabetes in whom diabetes was inadequately managed by GLP-1 RA therapy with or without additional oral glucose-lowering medications, once-weekly IcoSema demonstrated statistical superiority to semaglutide 1.0 mg with respect to HbA 1c reduction from baseline to week 52

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