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Diabetes Obes Metab 20(3):479487 Hayward RA, Reaven PD, Wiitala WL, Bahn GD, Reda DJ, Ge L, VADT Investigators et al (2015) Follow-up of glycemic control and cardiovascular outcomes in type 2 diabetes

This is especially true with the new class of drugs being used for weight loss

In addition, These incretin hormones bind to receptors in the pancreas to attenuate rising postprandial glucose levels

Final Thoughts While natural GLP-1 agonists hold significant promise, further research is needed to establish their long-term efficacy and safety

By contrast, peptides such as PYY and apelin were discontinued primarily due to formulation limitations or tolerability at supraphysiologic dosespharmacologic rather than biological failuresand therefore meet criteria for re-evaluation