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As demonstrated by oxyntomodulin, a weak endogenous agonist for GLP-1 receptor and glucagon receptor, a strategy that simultaneously stimulates both GLP-1 and glucagon receptors can reduce food intake while increasing energy expenditure, synergistically enhancing weight loss [105-107]

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GLP-1R may upregulate the expression levels of ABCA1, and previous studies have indicated that ABCA1 serves an important role in airway inflammation (23,27)

Supporting healthy blood sugar metabolism can ease the metabolic shift many GLP-1 users feel, she explains

Others see it as a concern, because the tirzepatide dosing and management protocols require a different kind of clinical attention than TRT does