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In early January 2024, the FDA investigated several of these medications Ozempic (semaglutide, Novo Nordisk), Wegovy (semaglutide, Novo Nordisk), Saxenda (liraglutide, Novo Nordisk) and two versions of the GIP/GLP-1 dual agonist tirzepatide for suicidal ideation concerns

References 1 GraafCdDonnellyDWoottenDLauJSextonPMMillerLJet al

Januvia, by contrast, is taken at a fixed dose of 100 mg once daily at any time, with or without food

Biology of human sodium glucose transporters

One possible mechanism is that DIV-1 may promote GSC maintenance and germline proliferation by maintaining a threshold for germline proliferation/differentiation decision below GLP-1/Notch activity (see Fig